하악골 신장술에서 압축자극을 통한 골재생시 TGF-β1, Osteonectin 및 BMP-4의 발현
EXPRESSION OF TGF-β1, OSTEONECTIN AND BMP-4 ON BONE REGENERATION IN MANDIBULAR DISTRACTION OSTEOGENESIS COMBINATION WITH A COMPRESSION STIMULATION
박성진, 김욱규, 정인교, 황대석, 김용덕, 신상훈, 김철훈, 변준호,
소속 상세정보
박성진 ( Park Seong-Jin ) - 부산대학교 치과대학 구강악안면외과학교실
김욱규 ( Kim Uk-Kyu ) - 부산대학교 치과대학 구강안면외과학교실
정인교 ( Jung In-Kyo ) - 부산대학교 치과대학 구강안면외과학교실
황대석 ( Hwang Dae-Seok ) - 부산대학교 치과대학 구강안면외과학교실
김용덕 ( Kim Yong-Deok ) - 부산대학교 치과대학 구강안면외과학교실
신상훈 ( Shin Sang-Hun ) - 부산대학교 치과대학 구강안면외과학교실
김철훈 ( Kim Chul-Hoon ) - 동아의료원 의과대학 구강악안면외과학교실
변준호 ( Byun June-Ho ) - 경상대학교 의과대학 구강악안면외과학교실
KMID : 0355620070330040288
Abstract
Distraction osteogenesis(DO) is a technique of lengthning bone including soft tissue by gradual separation of surgically divided bone surfaces.
Distraction osteogenesis combination with a compression stimulation(DO-CO) was a new technique by authors to enhance new bone quality and to shorten the consolidation period.
The purpose of this study was to compare DO with DO combined with compression force in efficiency by evaluating the expression of TGF-β1, osteonectin and BMP-4 on bone regenerate in rabbit mandible.
Fourty two rabbits were used for this experiment.
On the control group, the distraction was carried out at the rate of 1 ㎜ per day to obtain the amount of 8 ㎜ distraction for 8 days.
On the experimental group, the distraction was carried out at the rate of 1㎜ per day for 10 days, 3 days-latency period, and then the compression was carried out as counter direction 1 ㎜ per day for 2 days. After 0 day, 5 days, 13 days, 20 days, 27 days, 34 days and 41 days, three rabbits on each group were sacrificed and the distracted portion of mandible were cut and treated for RT-PCR observation. The level of expression of TGF-β1 and osteonectin were shown more and longer expression in the experimental group than in the control group. The expression of BMP-4 was maintained with high level during the entire experimental period in both groups.
These findings suggested that DO with compression stimulation could be a favorable technique for obtaining a good new bone quality.
키워드
Distraction osteogenesis;Compression;TGF-β1;Osteonectin;BMP-4
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